Formulation and characterization of topical microemulsion loaded with naproxen

The aim of this study was to prepare w/o Micro-emulsions naproxen for topical application & evaluate in vitro permeation Naproxen. On the basis ternary phase diagram and drug solubility test Tween-20, Oleic acid Polyethylene Glycol 400 selected these are eminently used as an appropriate transporting system introducing Naproxen transdermal delivery. physicochemical properties microemulsions such conductivity, droplet size, viscosity pH were measured. permeability compared with commercial microemulsions. rates from micro-emulsions higher (1.2 times) than marketed gel formulation. Finally, according histological examination did not show irritant effect on treated skin. In conclusion, results indicated that especially F5 formulation can be considered potentially useful vehicles application.